The present cross-sectional study correlated serum TSH (Thyroid stimulating hormone) levels with fasting bile cholesterol and TSH levels and with the type of stone in gallstone disease.

It developed a detailed proforma to record information regarding patients′ hospital details, age, sex, routine blood investigations, special investigations, and imaging study; and found-

• Forty-eight patients (22 male and 26 female) were diagnosed with gallstone disease.
• 23% of patients had elevated serum TSH without any history of thyroid disease.
• A maximum number of participants with elevated TSH fell in the 31-40 years category (5 out of 20), yet the higher proportion fell in the 41-50 years age group (42.9%, that is, 3 out of 7).
• 33% of patients showed elevated fasting bile TSH levels with female preponderance, even higher than the number of those with elevated serum TSH levels.
• Many participants with elevated bile TSH fell in the 31-40 years age group (8 out of 20); however, the proportion was higher in the 41-50 years age group (57.1%, that is, 4 out of 7).

Thus, there exists a significant independent relationship between serum TSH and fasting bile TSH in female patients of gallstone disease. Subclinical hypothyroidism has a crucial role in cholesterol cholelithiasis, especially in women.

Tippisetty V, Kumar Y. Thyroid Stimulating Hormone Correlation with Analysis of Fasting Bile and Stone in Gallstone Diseases. Journal of Surgery and Research. 2021; 4: 532-538.